The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

Yasushi Uematsu; Kirsten FischerLindahl; Michael Steinmetz

doi:10.1007/BF00351082

The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

Yasushi Uematsu, Kirsten FischerLindahl, Michael Steinmetz

Immunology

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the A_β2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/A_β3and A_β3/A_β2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

Original language	English (US)
Pages (from-to)	96-101
Number of pages	6
Journal	Immunogenetics
Volume	27
Issue number	2
DOIs	https://doi.org/10.1007/BF00351082
State	Published - Feb 1 1988

ASJC Scopus subject areas

Immunology
Genetics

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10.1007/BF00351082

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title = "The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes",

abstract = "Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.",

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T1 - The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

AU - Uematsu, Yasushi

AU - FischerLindahl, Kirsten

AU - Steinmetz, Michael

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N2 - Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

AB - Four recombinational breakpoints were mapped in the K-A interval of the mouse major histocompatibility complex (MHC) by Southern blot analysis. The breakpoint in B10.SBR, containing a b/s recombinant MHC haplotype, is located about 45 kb upstream of the Aβ2gene close to the breakpoint in B10.AQR. Crossover in two cas3/cas4 and one cas4/cas3 recombinant haplotypes has taken place in the previously identified K/Aβ3and Aβ3/Aβ2recombinational hot spots. The same hot spots are thus active in crossover between two Mus musculus castaneus MHC haplotypes and in crossover between a laboratory and a M. m. castaneus MHC haplotype.

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The same MHC recombinational hot spots are active in crossing-over between wild/wild and wild/inbred mouse chromosomes

Abstract

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