Abstract
The Saccharomyces cerevisiae gene MEC1 represents a structural homolog of the human gene ATM mutated in ataxia telangiectasia patients. Like human ataxia telangiectasia cell lines, mec1 mutants are defective in G2 and S- phase cell cycle checkpoints in response to radiation treatment. Here we show an additional defect in G1 arrest following treatment with UV light or gamma rays and map a defective arrest stage at or upstream of START in the yeast cell cycle.
Original language | English (US) |
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Pages (from-to) | 5841-5843 |
Number of pages | 3 |
Journal | Journal of bacteriology |
Volume | 178 |
Issue number | 19 |
DOIs | |
State | Published - 1996 |
ASJC Scopus subject areas
- Microbiology
- Molecular Biology