@inbook{561f5871e32b4c09ad61185d054423fd,
title = "The Roles of Cullin-2 E3 Ubiquitin Ligase Complex in Cancer",
abstract = "Posttranslational protein modifications play an important role in regulating protein stability and cellular function. There are at least eight Cullin family members. Among them, Cullin-2 forms a functional E3 ligase complex with elongin B, elongin C, RING-box protein 1 (RBX1, also called ROC1), as well as the substrate recognition subunit (SRS) to promote the substrate ubiquitination and degradation. In this book chapter, we will review Cullin-2 E3 ligase complexes that include various SRS proteins, including von Hippel Lindau (pVHL), leucine-rich repeat protein-1 (LRR-1), preferentially expressed antigen of melanoma (PRAME), sex-determining protein FEM-1 and early embryogenesis protein ZYG-11. We will focus on the VHL signaling pathway in clear cell renal cell carcinoma (ccRCC), which may reveal various therapeutic avenues in treating this lethal cancer.",
keywords = "Cancer, Cullin-2, E3 ubiquitin ligase, HIF, Hypoxia, VHL, ccRCC, pVHL",
author = "Xijuan Liu and Giada Zurlo and Qing Zhang",
note = "Publisher Copyright: {\textcopyright} Springer Nature Singapore Pte Ltd. 2020.",
year = "2020",
doi = "10.1007/978-981-15-1025-0_11",
language = "English (US)",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "173--186",
booktitle = "Advances in Experimental Medicine and Biology",
}