The Role of PIAS SUMO E3-Ligases in Cancer

Andrea Rabellino, Cristina Andreani, Pier Paolo Scaglioni

Research output: Contribution to journalReview articlepeer-review

72 Scopus citations


SUMOylation modifies the interactome, localization, activity, and lifespan of its target proteins. This process regulates several cellular machineries, including transcription, DNA damage repair, cell-cycle progression, and apoptosis. Accordingly, SUMOylation is critical in maintaining cellular homeostasis, and its deregulation leads to the corruption of a plethora of cellular processes that contribute to disease states. Among the proteins involved in SUMOylation, the protein inhibitor of activated STAT (PIAS) E3-ligases were initially described as transcriptional coregulators. Recent findings also indicate that they have a role in regulating protein stability and signaling transduction pathways. PIAS proteins interact with up to 60 cellular partners affecting several cellular processes, most notably immune regulation and DNA repair, but also cellular proliferation and survival. Here, we summarize the current knowledge about their role in tumorigenesis and cancer-related processes.

Original languageEnglish (US)
Pages (from-to)1542-1547
Number of pages6
JournalCancer research
Issue number7
StatePublished - 2017

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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