The role of inflammation and antiinflammation therapies in keratoconjunctivitis sicca

Koray Gumus, Harrison D Cavanagh

Research output: Contribution to journalReview articlepeer-review

46 Scopus citations


Purpose: To review and integrate recent advances in identifying the role of inflammation in the pathogenesis of dry eye conditions and the biological rationale and practical clinical aspects of newer, antiinflammatory theories. Methods: A comprehensive literature survey. Results and conclusion: Keratoconjunctivitis Sicca (KCS) is a multifactorial and complex disorder in which ocular surface inflammations play a central role. Identification of specific CD4-T-Cell pathways and the recent recognition of targeting of alpha-fodrin suggest a case for novel new therapeutic aspects such as anti-CD4 monoclonal antibodies, systemic linoleic and gamma-linolenic acids, and omega-6 essential fatty acids. Replacement of tear volume with nonpreserved wetting agents and standard typical antiinflammatory corticosteroid and/or cyclosporine A continues to be central current conventional therapy for KCS.

Original languageEnglish (US)
Pages (from-to)57-67
Number of pages11
JournalClinical Ophthalmology
Issue number1
StatePublished - Dec 1 2009


  • Antiinflammatory therapy
  • Dry eye
  • Keratoconjunctivitis sicca

ASJC Scopus subject areas

  • Ophthalmology


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