The role of endogenous and exogenous DNA damage and mutagenesis

Errol C. Friedberg, Lisa D. McDaniel, Roger A. Schultz

Research output: Contribution to journalReview articlepeer-review

124 Scopus citations


The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation.

Original languageEnglish (US)
Pages (from-to)5-10
Number of pages6
JournalCurrent Opinion in Genetics and Development
Issue number1
StatePublished - Feb 2004

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology


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