The role of endogenous and exogenous DNA damage and mutagenesis

Errol C. Friedberg; Lisa D. McDaniel; Roger A. Schultz

doi:10.1016/j.gde.2003.11.001

The role of endogenous and exogenous DNA damage and mutagenesis

Errol C. Friedberg, Lisa D. McDaniel, Roger A. Schultz

Research output: Contribution to journal › Review article › peer-review

129 Scopus citations

Abstract

The field of DNA damage responsiveness in general, and the consequences of endogenous and exogenous base damage in DNA, in particular, has made new and exciting contributions to our increasing understanding of the initiation and progression of neoplasia in humans. This article presents some of the highlights in this area of investigation, with a particular emphasis on DNA repair, the tolerance of DNA damage and its contribution to mutagenesis, and DNA damage checkpoint regulation.

Original language	English (US)
Pages (from-to)	5-10
Number of pages	6
Journal	Current Opinion in Genetics and Development
Volume	14
Issue number	1
DOIs	https://doi.org/10.1016/j.gde.2003.11.001
State	Published - Feb 2004

ASJC Scopus subject areas

Genetics
Developmental Biology

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10.1016/j.gde.2003.11.001

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The role of endogenous and exogenous DNA damage and mutagenesis

Abstract

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