The Role of Chromatin during Transcription

Bing Li; Michael Carey; Jerry L. Workman

doi:10.1016/j.cell.2007.01.015

The Role of Chromatin during Transcription

Bing Li, Michael Carey, Jerry L. Workman

Research output: Contribution to journal › Review article › peer-review

2742 Scopus citations

Abstract

Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.

Original language	English (US)
Pages (from-to)	707-719
Number of pages	13
Journal	Cell
Volume	128
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2007.01.015
State	Published - Feb 23 2007

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)

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10.1016/j.cell.2007.01.015

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title = "The Role of Chromatin during Transcription",

abstract = "Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.",

author = "Bing Li and Michael Carey and Workman, {Jerry L.}",

note = "Funding Information: We thank F. Asturias, E. Nogales, C. Peterson, P. Schultz, and members of the Workman Laboratory including S. Pattenden and T. Kusch for insightful discussions. This work is supported by NIGMS grant R37 GM047867 and the Stowers Institute for Medical Research.",

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AU - Li, Bing

AU - Carey, Michael

AU - Workman, Jerry L.

N1 - Funding Information: We thank F. Asturias, E. Nogales, C. Peterson, P. Schultz, and members of the Workman Laboratory including S. Pattenden and T. Kusch for insightful discussions. This work is supported by NIGMS grant R37 GM047867 and the Stowers Institute for Medical Research.

PY - 2007/2/23

Y1 - 2007/2/23

N2 - Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.

AB - Chromatin structure imposes significant obstacles on all aspects of transcription that are mediated by RNA polymerase II. The dynamics of chromatin structure are tightly regulated through multiple mechanisms including histone modification, chromatin remodeling, histone variant incorporation, and histone eviction. In this Review, we highlight advances in our understanding of chromatin regulation and discuss how such regulation affects the binding of transcription factors as well as the initiation and elongation steps of transcription.

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DO - 10.1016/j.cell.2007.01.015

M3 - Review article

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SN - 0092-8674

VL - 128

SP - 707

EP - 719

JO - Cell

JF - Cell

IS - 4

ER -

The Role of Chromatin during Transcription

Abstract

ASJC Scopus subject areas

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