The role of cachectin/TNF in endotoxic shock and cachexia

Anthony Ceramil, Bruce Beutler

Research output: Contribution to journalReview articlepeer-review

28 Scopus citations


The histories of tumor necrosis factor (TNF) and cachectin have recently converged, with the recognition that they are one and the same molecule. Cachectin/TNF appears to be a major factor in the pathology that accompanies invasion by a foreign organism - the host mounts an exagerated response that is itself debilatory. Here, Bruce Beutler and Anthony Cerami review the involvement of cachectin/TNF in wasting and shock, as well as its more beneficial influences.

Original languageEnglish (US)
Pages (from-to)28-31
Number of pages4
JournalTrends in Immunology
Issue number1-12
StatePublished - 1988

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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