@inproceedings{0bfcb4ef776f4f8fb7a1484230c3dab8,

title = "The properties of the cardiac cell mathematical model with the markovian representation of potassium channel gating processes under high pacing rate (computer simulation study)",

abstract = "A new formulation of potassium channel gating processes with the Markov representation for utilizing in the action potential (AP) mathematical models, is presented. In contrast to the Hodgkin's and Huxley's (H-H) representation, the Markovian representation provides interdependence of channel gating processes, which is closer to reality. This also allows the simulation of structural changes of channel proteins by implementing the corresponding modifications in the channels' kinetics. In computer simulation, it is observed that single early-after depolarizations (EAD) appear in the AP of wild-type myocardial cells with the Markovian representation of the IKr channels.",

keywords = "Cardiac cell model, Computer simulation, Early after-depolarization, Markovian representation",

author = "R. Samade and B. Kogan",

year = "2004",

language = "English (US)",

isbn = "1932415432",

series = "Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04",

pages = "371--377",

editor = "F. Valafar and H. Valafar",

booktitle = "Proceedings of the International Conference on Mathematics and Engineering Techniques in Medicine and Biological Sciences, METMBS'04",

note = "Proceedings of the International Conference on Mathematics and Engineering Techniques in medicine and Biological Sciences, METMBS'04 ; Conference date: 21-06-2004 Through 24-06-2004",

}