The promiscuous receptor — Prostate Cancer Comes of Age

J. D. Wilson

Research output: Contribution to journalEditorialpeer-review

4 Scopus citations


It has been known for almost a century that testosterone and its intracellular mediator, dihydrotestosterone, control the development and function of the prostate gland. Huggins and his colleagues used this knowledge to show that medical or surgical castration can cause regression of prostate cancer. This discovery led to one of the first, if not the first, effective therapies for prostate cancer.1 Unfortunately, prostate cancer continues to be a leading cause of death from cancer in men because the response to castration is usually brief, and few effective alternative therapies are available. Indeed, elucidation of the biology of this tumor lags.

Original languageEnglish (US)
Pages (from-to)1440-1441
Number of pages2
JournalNew England Journal of Medicine
Issue number21
StatePublished - May 25 1995

ASJC Scopus subject areas

  • Medicine(all)


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