TY - JOUR
T1 - The promiscuous receptor — Prostate Cancer Comes of Age
AU - Wilson, J. D.
PY - 1995/5/25
Y1 - 1995/5/25
N2 - It has been known for almost a century that testosterone and its intracellular mediator, dihydrotestosterone, control the development and function of the prostate gland. Huggins and his colleagues used this knowledge to show that medical or surgical castration can cause regression of prostate cancer. This discovery led to one of the first, if not the first, effective therapies for prostate cancer.1 Unfortunately, prostate cancer continues to be a leading cause of death from cancer in men because the response to castration is usually brief, and few effective alternative therapies are available. Indeed, elucidation of the biology of this tumor lags.
AB - It has been known for almost a century that testosterone and its intracellular mediator, dihydrotestosterone, control the development and function of the prostate gland. Huggins and his colleagues used this knowledge to show that medical or surgical castration can cause regression of prostate cancer. This discovery led to one of the first, if not the first, effective therapies for prostate cancer.1 Unfortunately, prostate cancer continues to be a leading cause of death from cancer in men because the response to castration is usually brief, and few effective alternative therapies are available. Indeed, elucidation of the biology of this tumor lags.
UR - http://www.scopus.com/inward/record.url?scp=0029025478&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0029025478&partnerID=8YFLogxK
U2 - 10.1056/NEJM199505253322109
DO - 10.1056/NEJM199505253322109
M3 - Editorial
C2 - 7723802
AN - SCOPUS:0029025478
SN - 0028-4793
VL - 332
SP - 1440
EP - 1441
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 21
ER -