The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C

ZhaoLan Tang; Philipp E. Scherer; Michael P. Lisanti

doi:10.1016/0378-1119(94)90087-6

The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C

ZhaoLan Tang, Philipp E. Scherer, Michael P. Lisanti

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Abstract

We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC, is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.

Original language	English (US)
Pages (from-to)	299-300
Number of pages	2
Journal	Gene
Volume	147
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(94)90087-6
State	Published - Sep 30 1994

Keywords

Caveolae
cell transformation
potocytosis
signalling
v-Src substrate

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(94)90087-6

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@article{3ed9795afbf74b1db9e37583e8d98e59,

title = "The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C",

abstract = "We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC, is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.",

keywords = "Caveolae, cell transformation, potocytosis, signalling, v-Src substrate",

author = "ZhaoLan Tang and Scherer, {Philipp E.} and Lisanti, {Michael P.}",

note = "Funding Information: We thank H.F. Lodish and G. Baldini for providing the cDNA library. This work was supported by an NIH FIRST Award (GM-50443 to M.P.L.) and a grant from the W.M. Keck Foundation to the Whitehead Fellows program. P.E.S. is funded by a Long-term EMBO fellowship and NIH grants (GM-49516 and DK-47618) to H.F. Lodish.",

year = "1994",

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doi = "10.1016/0378-1119(94)90087-6",

language = "English (US)",

volume = "147",

pages = "299--300",

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T1 - The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C

AU - Tang, ZhaoLan

AU - Scherer, Philipp E.

AU - Lisanti, Michael P.

N1 - Funding Information: We thank H.F. Lodish and G. Baldini for providing the cDNA library. This work was supported by an NIH FIRST Award (GM-50443 to M.P.L.) and a grant from the W.M. Keck Foundation to the Whitehead Fellows program. P.E.S. is funded by a Long-term EMBO fellowship and NIH grants (GM-49516 and DK-47618) to H.F. Lodish.

PY - 1994/9/30

Y1 - 1994/9/30

N2 - We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC, is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.

AB - We report here the cloning of the murine cDNA encoding caveolin, a known v-Src substrate and caveolar marker protein. Interestingly, analysis of the murine cDNA and comparison with caveolin from other species reveals a previously unrecognized consensus site for protein kinase C (PKC) phosphorylation. This finding could have important implications as (i) both the morphology and function of caveolae are dramatically affected by PKC activators; and (ii) PKC, is concentrated in isolated caveolin-rich membrane domains. In addition, this first step should facilitate the use of the mouse as a genetic system for elucidating the role of caveolin in caveolar functioning.

KW - Caveolae

KW - cell transformation

KW - potocytosis

KW - signalling

KW - v-Src substrate

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DO - 10.1016/0378-1119(94)90087-6

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AN - SCOPUS:0028040775

SN - 0378-1119

VL - 147

SP - 299

EP - 300

JO - Gene

JF - Gene

IS - 2

ER -

The primary sequence of murine caveolin reveals a conserved consensus site for phosphorylation by protein kinase C

Abstract

Keywords

ASJC Scopus subject areas

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