The preventive effects of apolipoprotein mimetic D-4F from vibration injury-experiment in rats

David J. Rowe, Ji Geng Yan, Lin Ling Zhang, Kirkwood A. Pritchard, Dennis S. Kao, Hani S. Matloub, Danny A. Riley

Research output: Contribution to journalArticlepeer-review

5 Scopus citations


Hand-arm vibration syndrome (HAVS) is a debilitating sequela of neurological and vascular injuries caused by prolonged occupational exposure to hand-transmitted vibration. Our previous study demonstrated that short-term exposure to vibration can induce vasoconstriction and endothelial cell damage in the ventral artery of the rat's tail. The present study investigated whether pretreatment with D-4F, an apolipoprotein A-1 mimetic with known anti-oxidant and vasodilatory properties, prevents vibration-induced vasoconstriction, endothelial cell injury, and protein nitration. Rats were injected intraperitoneally with 3 mg/kg D-4F at 1 h before vibration of the tails for 4 h/day at 60 Hz, 49 m/s2 r. m. s. acceleration for either 1 or 3 days. Vibration-induced endothelial cell damage was examined by light microscopy and nitrotyrosine immunoreactivity (a marker for free radical production). One and 3-day vibration produced vasoconstriction and increased nitrotyrosine. Preemptive treatment with D-4F prevented these negative changes. These findings suggest that D-4F may be useful in the prevention of HAVS.

Original languageEnglish (US)
Pages (from-to)64-70
Number of pages7
Issue number1
StatePublished - Mar 2011


  • Apolipoprotein mimetic
  • D-4F
  • Endothelial cell injury
  • HAVS
  • Hand arm vibration syndrome
  • Occupational Raynaud's
  • Vasoconstriction
  • Vibration injury

ASJC Scopus subject areas

  • Surgery
  • Orthopedics and Sports Medicine


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