The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

Zhong Jian Shen; Stephane Esnault; James S. Malter

doi:10.1038/ni1266

The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

Zhong Jian Shen, Stephane Esnault, James S. Malter

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element -binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.

Original language	English (US)
Pages (from-to)	1280-1287
Number of pages	8
Journal	Nature immunology
Volume	6
Issue number	12
DOIs	https://doi.org/10.1038/ni1266
State	Published - Dec 2005

ASJC Scopus subject areas

Immunology and Allergy
Immunology

Access to Document

10.1038/ni1266

Cite this

@article{97b82286dfe54121b8e706d50015406f,

title = "The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils",

abstract = "The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element -binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.",

author = "Shen, {Zhong Jian} and Stephane Esnault and Malter, {James S.}",

note = "Funding Information: We thank J. Sedgwick for eosinophils; K.P. Lu (Harvard University, Boston, Massachusetts) for the Pin1 WW domain cDNA; N. Jarjour for bronchoscopy samples; P. Bertics for critical reading of the manuscript; and members of the lab and the UW-Asthma SCOR group for suggestions. Supported by the National Institutes of Health (P50HL56396 to J.S.M.).",

year = "2005",

month = dec,

doi = "10.1038/ni1266",

language = "English (US)",

volume = "6",

pages = "1280--1287",

journal = "Nature immunology",

issn = "1529-2908",

publisher = "Nature Research",

number = "12",

}

TY - JOUR

T1 - The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

AU - Shen, Zhong Jian

AU - Esnault, Stephane

AU - Malter, James S.

N1 - Funding Information: We thank J. Sedgwick for eosinophils; K.P. Lu (Harvard University, Boston, Massachusetts) for the Pin1 WW domain cDNA; N. Jarjour for bronchoscopy samples; P. Bertics for critical reading of the manuscript; and members of the lab and the UW-Asthma SCOR group for suggestions. Supported by the National Institutes of Health (P50HL56396 to J.S.M.).

PY - 2005/12

Y1 - 2005/12

N2 - The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element -binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.

AB - The infiltration, accumulation and degranulation of eosinophils in the lung represents a hallmark of active asthma. In vivo or in vitro eosinophil activation triggers the secretion of the antiapoptotic cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF). We now identify Pin1, a cis-trans isomerase, as an essential component of the ribonucleoprotein complex responsible for GM-CSF mRNA stabilization, cytokine secretion and the survival of activated eosinophils. Pin1 regulated the association of the AU-rich element -binding proteins AUF1 and hnRNP C with GM-CSF mRNA, accelerating or slowing decay, respectively. These data indicate Pin1 is a key mediator of GM-CSF production.

UR - http://www.scopus.com/inward/record.url?scp=30044436160&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30044436160&partnerID=8YFLogxK

U2 - 10.1038/ni1266

DO - 10.1038/ni1266

M3 - Article

C2 - 16273101

AN - SCOPUS:30044436160

SN - 1529-2908

VL - 6

SP - 1280

EP - 1287

JO - Nature immunology

JF - Nature immunology

IS - 12

ER -

The peptidyl-prolyl isomerase Pin1 regulates the stability of granulocyte-macrophage colony-stimulating factor mRNA in activated eosinophils

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this