The pathogenesis of Acanthamoeba keratitis

Jerry Y Niederkorn, Hassan Alizadeh, Henry Leher, James P McCulley

Research output: Contribution to journalArticlepeer-review

151 Scopus citations


Free-living amoebae of the genus Acanthamoeba produce a progressive, blinding infection of the corneal surface. The pathogenesis of Acanthamoeba keratitis involves parasite-mediated cytolysis and phagocytosis of corneal epithelial cells and induction of programmed cell death. Acanthamoeba spp. elaborate a variety of proteases which may facilitate cytolysis of the corneal epithelium, invasion of the extracellular matrix, and dissolution of the corneal stromal matrix.

Original languageEnglish (US)
Pages (from-to)437-443
Number of pages7
JournalMicrobes and Infection
Issue number6
StatePublished - May 1999


  • Amoeba
  • Cornea
  • Keratitis
  • Ocular
  • Pathogenesis

ASJC Scopus subject areas

  • Microbiology
  • Immunology
  • Infectious Diseases


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