@article{f908934814514e26bb166d59e8a67882,
title = "The orexigenic hormone ghrelin defends against depressive symptoms of chronic stress",
abstract = "We found that increasing ghrelin levels, through subcutaneous injections or calorie restriction, produced anxiolytic- and antidepressant-like responses in the elevated plus maze and forced swim test. Moreover, chronic social defeat stress, a rodent model of depression, persistently increased ghrelin levels, whereas growth hormone secretagogue receptor (Ghsr) null mice showed increased deleterious effects of chronic defeat. Together, these findings demonstrate a previously unknown function for ghrelin in defending against depressive-like symptoms of chronic stress.",
author = "Michael Lutter and Ichiro Sakata and Sherri Osborne-Lawrence and Rovinsky, {Sherry A.} and Anderson, {Jason G.} and Saendy Jung and Birnbaum, {Shari G} and Masashi Yanagisawa and Elmquist, {Joel K} and Nestler, {Eric J.} and Zigman, {Jeffrey M}",
note = "Funding Information: The authors thank C.E. Lee, M. Choi and M. Perello. This work was supported by grants from the US National Institutes of Health (K08DK068069-01A2, R01DK71320, P01DK56116, RL1DK081185, P50MH66172 and ADA 1-06-JF-59), a Foundation for Prader-Willi Research Grant, a NARSAD Young Investigator Award and a University of Texas Southwestern Disease-Oriented Clinical Scholars Award. M.Y. is a Howard Hughes Medical Institute investigator.",
year = "2008",
month = jul,
doi = "10.1038/nn.2139",
language = "English (US)",
volume = "11",
pages = "752--753",
journal = "Nature neuroscience",
issn = "1097-6256",
publisher = "Nature Publishing Group",
number = "7",
}