The Nonlipid Effects of Statins on Endothelial Function

Joshua A. Beckman; Mark A. Creager

doi:10.1016/j.tcm.2006.03.003

The Nonlipid Effects of Statins on Endothelial Function

Joshua A. Beckman, Mark A. Creager

Research output: Contribution to journal › Review article › peer-review

58 Scopus citations

Abstract

Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.

Original language	English (US)
Pages (from-to)	156-162
Number of pages	7
Journal	Trends in Cardiovascular Medicine
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/j.tcm.2006.03.003
State	Published - Jul 2006
Externally published	Yes

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.tcm.2006.03.003

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title = "The Nonlipid Effects of Statins on Endothelial Function",

abstract = "Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.",

author = "Beckman, {Joshua A.} and Creager, {Mark A.}",

note = "Funding Information: This study was supported by grants from the National Institutes of Health (HL 56607, HL 48743). Dr Creager is the Simon C. Fireman scholar in cardiovascular medicine at the Brigham and Women's Hospital.",

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AU - Beckman, Joshua A.

AU - Creager, Mark A.

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N2 - Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.

AB - Hydroxymethylglutaryl-coenzyme A reductase inhibitors or statins constitute one of the wonder drugs of the last 2 decades. Use of this hypolipidemic medication class reduces morbidity and mortality in patients with a wide variety of cholesterol levels. Beneficial effects of the medication are seen in advance of changes in lipids suggesting nonlipid mechanisms may play a role in mediating these benefits of statins. One important nonlipid mechanism by which statins may improve vascular outcomes is restoration of normal endothelial cell function. This review will discuss the nonlipid effects of statins on endothelial cell function to highlight other avenues of benefit conferred by these medications.

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The Nonlipid Effects of Statins on Endothelial Function

Abstract

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