The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Joaquin Santolaya-Forgas; Ryan Townsend; Jacobo L. Santolaya; Priya Patel; Guadalupe Herrera-Garcia; V. Daniel Castracane

doi:10.1159/000441452

The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Joaquin Santolaya-Forgas, Ryan Townsend, Jacobo L. Santolaya, Priya Patel, Guadalupe Herrera-Garcia, V. Daniel Castracane

Research output: Contribution to journal › Review article › peer-review

2 Scopus citations

Abstract

The maternal microbiota has long been considered a potential cause for adverse perinatal outcomes. Gene expression regulators in prokaryotic and eukaryotic cells are influenced by changes in their microenvironments. We propose the novel idea that during in utero development, an adaptive and dynamic gene-regulatory cross talk might exist between the host genome and the maternal microbiota. Understanding these cross talks could increase the appreciation for the discovery of new diagnostics and therapeutics in maternal-fetal medicine.

Original language	English (US)
Pages (from-to)	1-3
Number of pages	3
Journal	Fetal Diagnosis and Therapy
Volume	39
Issue number	1
DOIs	https://doi.org/10.1159/000441452
State	Published - Jan 1 2016
Externally published	Yes

Keywords

Biological adaptation
Coevolution
Microbial invasion of the amniotic cavity
Microbiota
Microbiotal stimulus
Transcription factors

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Embryology
Radiology Nuclear Medicine and imaging
Obstetrics and Gynecology

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10.1159/000441452

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title = "The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine",

abstract = "The maternal microbiota has long been considered a potential cause for adverse perinatal outcomes. Gene expression regulators in prokaryotic and eukaryotic cells are influenced by changes in their microenvironments. We propose the novel idea that during in utero development, an adaptive and dynamic gene-regulatory cross talk might exist between the host genome and the maternal microbiota. Understanding these cross talks could increase the appreciation for the discovery of new diagnostics and therapeutics in maternal-fetal medicine.",

keywords = "Biological adaptation, Coevolution, Microbial invasion of the amniotic cavity, Microbiota, Microbiotal stimulus, Transcription factors",

author = "Joaquin Santolaya-Forgas and Ryan Townsend and Santolaya, {Jacobo L.} and Priya Patel and Guadalupe Herrera-Garcia and Castracane, {V. Daniel}",

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AU - Santolaya-Forgas, Joaquin

AU - Townsend, Ryan

AU - Santolaya, Jacobo L.

AU - Patel, Priya

AU - Herrera-Garcia, Guadalupe

AU - Castracane, V. Daniel

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N2 - The maternal microbiota has long been considered a potential cause for adverse perinatal outcomes. Gene expression regulators in prokaryotic and eukaryotic cells are influenced by changes in their microenvironments. We propose the novel idea that during in utero development, an adaptive and dynamic gene-regulatory cross talk might exist between the host genome and the maternal microbiota. Understanding these cross talks could increase the appreciation for the discovery of new diagnostics and therapeutics in maternal-fetal medicine.

AB - The maternal microbiota has long been considered a potential cause for adverse perinatal outcomes. Gene expression regulators in prokaryotic and eukaryotic cells are influenced by changes in their microenvironments. We propose the novel idea that during in utero development, an adaptive and dynamic gene-regulatory cross talk might exist between the host genome and the maternal microbiota. Understanding these cross talks could increase the appreciation for the discovery of new diagnostics and therapeutics in maternal-fetal medicine.

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KW - Coevolution

KW - Microbial invasion of the amniotic cavity

KW - Microbiota

KW - Microbiotal stimulus

KW - Transcription factors

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The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Abstract

Keywords

ASJC Scopus subject areas

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