The Microbiota and Transgenomic Networks: Potential Implications for Maternal-Fetal Medicine

Joaquin Santolaya-Forgas, Ryan Townsend, Jacobo L. Santolaya, Priya Patel, Guadalupe Herrera-Garcia, V. Daniel Castracane

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


The maternal microbiota has long been considered a potential cause for adverse perinatal outcomes. Gene expression regulators in prokaryotic and eukaryotic cells are influenced by changes in their microenvironments. We propose the novel idea that during in utero development, an adaptive and dynamic gene-regulatory cross talk might exist between the host genome and the maternal microbiota. Understanding these cross talks could increase the appreciation for the discovery of new diagnostics and therapeutics in maternal-fetal medicine.

Original languageEnglish (US)
Pages (from-to)1-3
Number of pages3
JournalFetal Diagnosis and Therapy
Issue number1
StatePublished - Jan 1 2016
Externally publishedYes


  • Biological adaptation
  • Coevolution
  • Microbial invasion of the amniotic cavity
  • Microbiota
  • Microbiotal stimulus
  • Transcription factors

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Embryology
  • Radiology Nuclear Medicine and imaging
  • Obstetrics and Gynecology


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