The mGluR theory of fragile X mental retardation

Mark F. Bear, Kimberly M. Huber, Stephen T. Warren

Research output: Contribution to journalArticlepeer-review

1309 Scopus citations


Many of the diverse functional consequences of activating group 1 metabotropic glutamate receptors require translation of pre-existing mRNA near synapses. One of these consequences is long-term depression (LTD) of transmission at hippocampal synapses. Loss of fragile X mental retardation protein (FMRP), the defect responsible for fragile X syndrome in humans, increases LTD in mouse hippocampus. This finding is consistent with the growing evidence that FMRP normally functions as a repressor of translation of specific mRNAs. Here we present a theory that can account for diverse neurological and psychiatric aspects of fragile X syndrome, based on the assumption that many of the protein-synthesis-dependent functions of metabotropic receptors are exaggerated in fragile X syndrome. The theory suggests new directions for basic research as well as novel therapeutic approaches for the treatment of humans with fragile X, the most frequent inherited cause of mental retardation and an identified cause of autism.

Original languageEnglish (US)
Pages (from-to)370-377
Number of pages8
JournalTrends in Neurosciences
Issue number7
StatePublished - Jul 2004

ASJC Scopus subject areas

  • Neuroscience(all)


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