@article{0b97481376c04c9190059fc613d1b204,
title = "The Mechanisms of Action of Tumor Treating Fields",
abstract = "Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.",
author = "Moser, {Justin C.} and Ellaine Salvador and Karina Deniz and Kenneth Swanson and Jack Tuszynski and Carlson, {Kristen W.} and Karanam, {Narasimha Kumar} and Patel, {Chirag B.} and Michael Story and Emil Lou and Carsten Hagemann",
note = "Funding Information: J. Moser reports other support from Novocure during the conduct of the study; personal fees from BMS, Amunix, Thirona Bio, Adagene, and Imaging Endpoints; other support from Novocure, Genentech, Alpine Immune Sciences, Amgen, Trishula Therapeutics, BioEclipse Therapeutics, FujiFilm, ImmunSensor, Simcha, Repertiore Immune Sciences, Nektar Therapeutics, Synthorx Inc., from Istari Oncology, Ideaya Biosciences, Rubius Therapeutics, University of Arziona, and Senwha Biosciences; personal fees from Caris Life Sciences, Daiichi-Sankyo, TGen, and Immunocore outside the submitted work. E. Salvador reports grants from Novocure Ltd. during the conduct of the study. K.D. Swanson reports grants and other support from Novocure Publisher Copyright: {\textcopyright} 2022 The Authors; Published by the American Association for Cancer Research.",
year = "2022",
month = oct,
day = "15",
doi = "10.1158/0008-5472.CAN-22-0887",
language = "English (US)",
volume = "82",
pages = "3650--3658",
journal = "Cancer research",
issn = "0008-5472",
number = "20",
}