The Mechanisms of Action of Tumor Treating Fields

Justin C. Moser, Ellaine Salvador, Karina Deniz, Kenneth Swanson, Jack Tuszynski, Kristen W. Carlson, Narasimha Kumar Karanam, Chirag B. Patel, Michael Story, Emil Lou, Carsten Hagemann

Research output: Contribution to journalReview articlepeer-review

9 Scopus citations


Tumor treating fields (TTFields), a new modality of cancer treatment, are electric fields transmitted transdermally to tumors. The FDA has approved TTFields for the treatment of glioblastoma multiforme and mesothelioma, and they are currently under study in many other cancer types. While antimitotic effects were the first recognized biological anticancer activity of TTFields, data have shown that tumor treating fields achieve their anticancer effects through multiple mechanisms of action. TTFields therefore have the ability to be useful for many cancer types in combination with many different treatment modalities. Here, we review the current understanding of TTFields and their mechanisms of action.

Original languageEnglish (US)
Pages (from-to)3650-3658
Number of pages9
JournalCancer research
Issue number20
StatePublished - Oct 15 2022
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


Dive into the research topics of 'The Mechanisms of Action of Tumor Treating Fields'. Together they form a unique fingerprint.

Cite this