The mammalian Mediator complex and its role in transcriptional regulation

Ronald C. Conaway, Shigeo Sato, Chieri Tomomori-Sato, Tingting Yao, Joan W. Conaway

Research output: Contribution to journalReview articlepeer-review

235 Scopus citations


Mediator is an essential component of the RNA polymerase II general transcriptional machinery and plays a crucial part in the activation and repression of eukaryotic mRNA synthesis. The Saccharomyces cerevisiae Mediator was the first to be defined and is a high molecular mass complex composed of >20 distinct subunits that performs multiple activities in transcription. Recent studies have defined the subunit composition and associated activities of mammalian Mediator, and revealed a striking evolutionary conservation of Mediator structure and function from yeast to man.

Original languageEnglish (US)
Pages (from-to)250-255
Number of pages6
JournalTrends in biochemical sciences
Issue number5
StatePublished - May 2005
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology


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