The Los Angeles and Savary-Miller systems for grading esophagitis: Utilization and correlation with histology

R. M. Genta, S. J. Spechler, A. F. Kielhorn

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


The aim of the study is to determine the proportion of patients who have esophageal biopsy specimens taken for an endoscopic diagnosis of reflux esophagitis in which an endoscopic grade of esophagitis (Los Angeles [LA] or Savary-Miller [SM]) is communicated to the pathologist, and to evaluate the correlation between those endoscopic grades and histopathologic findings. We searched the database of Caris Diagnostics (a large, gastrointestinal pathology practice that receives specimens from community-based endoscopy centers), and extracted data from all patients who had an endoscopy with esophageal biopsies submitted in a 12-month period. There were esophageal biopsy specimens from 49 480 patients obtained during 58 986 endoscopies. The LA grade was provided in 5513 cases (27.9% of 19 778 with endoscopic esophagitis); the SM grade was stated in only 2416 cases (12.2%). A histopathologic diagnosis of erosive or ulcerative esophagitis was made significantly less often in LA grade A patients (3.2%) than in those with LA grades C (20.0%) and D (23.3%); erosive or ulcerative esophagitis was found in only 1.4% of patients with SM grade I and in 35.5% of cases with grade IV. Endoscopists who biopsy the esophagus of patients with reflux esophagitis usually do not communicate the grade of esophagitis to the pathologist. Although both the LA and SM grading systems are based on the presence of esophageal mucosal breaks (erosions or ulcers), in practice such breaks are documented in only a minority of esophageal biopsy specimens taken from patients with reflux esophagitis of any grade.

Original languageEnglish (US)
Pages (from-to)10-17
Number of pages8
JournalDiseases of the Esophagus
Issue number1
StatePublished - Jan 1 2011


  • Esophageal biopsy
  • Esophagitis
  • Histopathology
  • Los Angeles grades
  • Savary-Miller

ASJC Scopus subject areas

  • Gastroenterology


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