TY - JOUR
T1 - The influence of gender, race, and marital status on survival in lung cancer patients
T2 - Analysis of radiation therapy oncology group trials
AU - Siddiqui, Farzan
AU - Bae, Kyounghwa
AU - Langer, Corey J.
AU - Coyne, James C.
AU - Gamerman, Victoria
AU - Komaki, Ritsuko
AU - Choy, Hak
AU - Curran, Walter J.
AU - Watkins-Bruner, Deborah
AU - Movsas, Benjamin
N1 - Funding Information:
Supported by RTOG U10 CA21661 and CCOP U10 CA37422 grants from the NCI. The contents of the article are the sole responsibility of the authors and do not necessarily represent the official views of the NCI.
PY - 2010/5
Y1 - 2010/5
N2 - Objective: A meta-analysis was conducted to determine the influence of gender, race, and marital status on overall survival (OS) in Radiation Therapy Oncology Group nonoperative non-small cell lung cancer trials. Materials and Methods: Data from 1365 patients treated on nine prospective Radiation Therapy Oncology Group studies activated during the 1990s were analyzed. Impact of gender, marital status, and race was considered in the Cox proportional hazards models. Age, Karnofsky performance status, weight loss, stage, histology, location of primary tumor, biologic equivalent dose, deviation from protocol dose, and education level were adjusted in the model. A two-sided p value <0.05 was considered statistically significant. Results: Males had significantly higher mortality than females adjusted for other covariates (hazard ratio [HR] = 1.22, 95% confidence interval = 1.08-1.38). Race and marital status were not independently predictive for OS. Single females had significantly better OS than single males (HR = 0.72), and married males had lower OS than single females (HR = 1.36). Conclusions: These results suggest that although certain subgroups of gender, race, and/or marital status have better outcomes with respect to OS; gender seems to be the most significant factor influencing survival results among nonoperative non-small cell lung cancer patients.
AB - Objective: A meta-analysis was conducted to determine the influence of gender, race, and marital status on overall survival (OS) in Radiation Therapy Oncology Group nonoperative non-small cell lung cancer trials. Materials and Methods: Data from 1365 patients treated on nine prospective Radiation Therapy Oncology Group studies activated during the 1990s were analyzed. Impact of gender, marital status, and race was considered in the Cox proportional hazards models. Age, Karnofsky performance status, weight loss, stage, histology, location of primary tumor, biologic equivalent dose, deviation from protocol dose, and education level were adjusted in the model. A two-sided p value <0.05 was considered statistically significant. Results: Males had significantly higher mortality than females adjusted for other covariates (hazard ratio [HR] = 1.22, 95% confidence interval = 1.08-1.38). Race and marital status were not independently predictive for OS. Single females had significantly better OS than single males (HR = 0.72), and married males had lower OS than single females (HR = 1.36). Conclusions: These results suggest that although certain subgroups of gender, race, and/or marital status have better outcomes with respect to OS; gender seems to be the most significant factor influencing survival results among nonoperative non-small cell lung cancer patients.
KW - Non-small cell lung cancer
KW - Sociodemographic factors
KW - Survival
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U2 - 10.1097/JTO.0b013e3181d5e46a
DO - 10.1097/JTO.0b013e3181d5e46a
M3 - Article
C2 - 20432520
AN - SCOPUS:77951860733
SN - 1556-0864
VL - 5
SP - 631
EP - 639
JO - Journal of Thoracic Oncology
JF - Journal of Thoracic Oncology
IS - 5
ER -