TY - JOUR
T1 - The inconvenience of convenience cohorts
T2 - Rhabdomyosarcoma and the PAX-FOXO1 biomarker
AU - Rosenberg, Abby R.
AU - Skapek, Stephen X.
AU - Hawkins, Douglas S.
PY - 2012/7
Y1 - 2012/7
N2 - "Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.
AB - "Convenience cohorts" comprise individuals thought to represent the general population, but chosen because they are readily available for evaluation, rather than at random. As such, these methods are subject to bias and may be misleading. Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma. However, retrospective studies assessing the role of PAX-FOXO1 translocations have yielded inconsistent results. This review highlights the findings from several clinical correlation studies of the PAX-FOXO1 biomarker and illustrates the challenges of using such methods to draw clinical conclusions.
UR - http://www.scopus.com/inward/record.url?scp=84863564132&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84863564132&partnerID=8YFLogxK
U2 - 10.1158/1055-9965.EPI-12-0207
DO - 10.1158/1055-9965.EPI-12-0207
M3 - Review article
C2 - 22564868
AN - SCOPUS:84863564132
SN - 1055-9965
VL - 21
SP - 1012
EP - 1018
JO - Cancer Epidemiology Biomarkers and Prevention
JF - Cancer Epidemiology Biomarkers and Prevention
IS - 7
ER -