Abstract
The mechanism of somatic hypermutation of immunoglobulin genes is not known, but appears to be linked to transcription and perhaps DNA repair. In order to determine if global DNA repair or the repair of the nontranscribed DNA strand is required for somatic mutation, we have analysed mice whose XP- C gene was inactivated by homologous recombination. Our study shows that hypermutation occurs in XP-C knockout mice with a normal frequency, suggesting that the XP-C gene product is not required for somatic hypermutation. Furthermore, we found that Ig gene switch recombination also is normal in these mice.
Original language | English (US) |
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Pages (from-to) | 527-533 |
Number of pages | 7 |
Journal | Molecular Immunology |
Volume | 34 |
Issue number | 7 |
DOIs | |
State | Published - May 1997 |
Keywords
- DNA repair
- Immunoglobulin genes
- Somatic mutation
ASJC Scopus subject areas
- Immunology
- Molecular Biology