TY - JOUR
T1 - The impact of moderate distance recreational running and ageing on cardiac physiology
AU - Kim, Jonathan H.
AU - Ko, Yi An
AU - Hedley, Jeff
AU - MacNamara, James
AU - Awad, Mosaab
AU - Taylor, William
AU - Healy, Sean
AU - Aida, Hiroshi
AU - Le, Ngoc Anh
AU - Wilson, Peter W.
AU - White, Melissa
AU - Sperling, Laurence S.
AU - Wilson, Joseph S.
AU - Baggish, Aaron L.
N1 - Funding Information:
JHK is supported by the National Institutes of Health (K23 HL128795).
PY - 2017/2/1
Y1 - 2017/2/1
N2 - Objective Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown. Methods 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18-20 years old, N=19); group 2 (45-50 years old, N=27); group 3 (70-75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race. Results Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and highsensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3δ 16±22 pg/mL, p=0.001), hs-CRP increased only among younger runners (group 1δ 1.5±2.7 mg/L, p=0.03) and cTnI increased in both younger (group 1δ 0.01±0.02 ng/mL, p=0.028) and older (group 3δ 0.01±0.01 ng/mL, p=0.007) runners, but not middle aged runners (group 2δ 0.00±0.00 ng/mL, p=0.57). Conclusions Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.
AB - Objective Exercise-induced cardiac dysfunction and corollary biomarker release have been documented following long-distance running events. To what degree these processes occur during shorter distance running events is unknown. Methods 72 healthy recreational runners (54% male/46% female) recruited by age (group 1 (18-20 years old, N=19); group 2 (45-50 years old, N=27); group 3 (70-75 years old, N=26)) were studied with echocardiography and biochemical profiling during participation in a 10 km running race. Results Despite age-dependent baseline differences in ventricular size and diastolic tissue velocities, there were no significant within group or across group decrements in ventricular systolic or diastolic function following race completion. Postrace increases in cardiac troponin-I (cTnI), B-type natriuretic peptide (BNP) and highsensitivity C-reactive protein (hs-CRP) were common and demonstrated distinct age dependent profiles. Specifically, BNP increases were most pronounced among older runners (group 3δ 16±22 pg/mL, p=0.001), hs-CRP increased only among younger runners (group 1δ 1.5±2.7 mg/L, p=0.03) and cTnI increased in both younger (group 1δ 0.01±0.02 ng/mL, p=0.028) and older (group 3δ 0.01±0.01 ng/mL, p=0.007) runners, but not middle aged runners (group 2δ 0.00±0.00 ng/mL, p=0.57). Conclusions Moderate distance recreational running leads to distinct age-dependent biomarker release but is not associated with cardiac fatigue, a proposed stimulus for pathologic cardiac remodelling that has been observed following longer distance running events.
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U2 - 10.1136/heartjnl-2016-310059
DO - 10.1136/heartjnl-2016-310059
M3 - Article
C2 - 27530134
AN - SCOPUS:84983567899
SN - 1355-6037
VL - 103
SP - 219
EP - 226
JO - Heart
JF - Heart
IS - 3
ER -