The hypothalamic regulation of metabolic adaptations to exercise

T. Fujikawa, C. M. Castorena, S. Lee, J. K. Elmquist

Research output: Contribution to journalReview articlepeer-review

14 Scopus citations


Our modern lifestyle is characterised by easy access to nutrient dense foods combined with limited physical activity. A sedentary lifestyle is one of several factors that have contributed to the global obesity epidemic and it also predisposes to chronic illnesses such as diabetes and cardiovascular disease. Although many studies have focused on the benefits of exercise in peripheral tissues, the contributions of the central nervous system to these exercise-induced metabolic adaptations are relatively unknown. The present review highlights the role of the ventromedial hypothalamus in regulating the metabolic response to exercise.

Original languageEnglish (US)
Article numbere12533
JournalJournal of Neuroendocrinology
Issue number10
StatePublished - Oct 2017


  • energy expenditure
  • exercise
  • hypothalamus
  • metabolism
  • ventromedial hypothalamus

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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