The hyperleptinemia of obesity - Regulator of caloric surpluses

Roger H Unger

Research output: Contribution to journalReview articlepeer-review

66 Scopus citations


New evidence suggests that leptin and other anorexigenic agents reduce appetite by inactivating hypothalamic AMP-activated protein kinase (AMPK), thereby increasing malonyl CoA levels. This preview examines AMP biology and its role in malonyl-CoA generation and attempts to integrate its central actions with its peripheral antilipotoxic actions within the context of leptin physiology in obesity.

Original languageEnglish (US)
Pages (from-to)145-146
Number of pages2
Issue number2
StatePublished - Apr 16 2004

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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