TY - JOUR
T1 - The first step in an investigation of quantitative ultrasound as a technique for evaluating infant bone strength
AU - Soto Martinez, Miriam E.
AU - Love, Jennifer C.
AU - Crowder, Christian
AU - Wiersema, Jason M.
AU - Pinto, Deborrah C.
AU - Derrick, Sharon M.
AU - Gao, Si
AU - Fleischman, Julie M.
AU - Greeley, Christopher
AU - Donaruma-Kwoh, Marcella
AU - Bachim, Angela
N1 - Funding Information:
Financial support provided by the Texas Center for the Judiciary ‐ Children's Justice Act (Grant #’s 13‐10, 14‐03, 15‐02, 16‐07, 17‐03, 18‐05, 19‐01).
Publisher Copyright:
© 2020 American Academy of Forensic Sciences
PY - 2021/3
Y1 - 2021/3
N2 - This study's purpose is to evaluate whether bone speed of sound (SOS) data, a parameter of quantitative ultrasound, collected from an infant autopsy sample are comparable to data collected from healthy, living infants. We hypothesize that SOS values obtained from deceased term-born infants will fall within the normal range for healthy, living infants. The study sample consists of 351 deceased infants between the ages of 30 weeks gestation at birth to 1 year postnatal at the time of death receiving autopsies at the Harris County Institute of Forensic Sciences or Texas Children's Hospital in Houston, TX. Various multivariate and univariate statistics were used to examine the relationship between SOS and age, prematurity, and chronic illness. The results of an ANOVA comparing the study sample data to published data from healthy, living infants indicate the SOS data are comparable. Additionally, a MANOVA indicated significant differences in SOS related to prematurity (p = 0.001) and age (p < 0.001). Mean SOS was significantly greater among term-born infants (M = 3065.66, SD =165.05) than premature infants (M = 2969.71, SD =192.72). Age had a significant polynomial (cubic) relationship with SOS for both the premature and term groups (p < 0.001). Results suggest that bone from an infant autopsy sample is an appropriate surrogate to examine the relationship between SOS and determinants of bone strength. Therefore, future research will use this study sample to investigate the relationship between SOS and determinants of bone strength in infants.
AB - This study's purpose is to evaluate whether bone speed of sound (SOS) data, a parameter of quantitative ultrasound, collected from an infant autopsy sample are comparable to data collected from healthy, living infants. We hypothesize that SOS values obtained from deceased term-born infants will fall within the normal range for healthy, living infants. The study sample consists of 351 deceased infants between the ages of 30 weeks gestation at birth to 1 year postnatal at the time of death receiving autopsies at the Harris County Institute of Forensic Sciences or Texas Children's Hospital in Houston, TX. Various multivariate and univariate statistics were used to examine the relationship between SOS and age, prematurity, and chronic illness. The results of an ANOVA comparing the study sample data to published data from healthy, living infants indicate the SOS data are comparable. Additionally, a MANOVA indicated significant differences in SOS related to prematurity (p = 0.001) and age (p < 0.001). Mean SOS was significantly greater among term-born infants (M = 3065.66, SD =165.05) than premature infants (M = 2969.71, SD =192.72). Age had a significant polynomial (cubic) relationship with SOS for both the premature and term groups (p < 0.001). Results suggest that bone from an infant autopsy sample is an appropriate surrogate to examine the relationship between SOS and determinants of bone strength. Therefore, future research will use this study sample to investigate the relationship between SOS and determinants of bone strength in infants.
KW - bone quality
KW - bone strength
KW - forensic anthropology
KW - infants
KW - quantitative ultrasound
KW - speed of sound
UR - http://www.scopus.com/inward/record.url?scp=85094655225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85094655225&partnerID=8YFLogxK
U2 - 10.1111/1556-4029.14605
DO - 10.1111/1556-4029.14605
M3 - Article
C2 - 33112476
AN - SCOPUS:85094655225
SN - 0022-1198
VL - 66
SP - 456
EP - 469
JO - Journal of Forensic Sciences
JF - Journal of Forensic Sciences
IS - 2
ER -