TY - JOUR
T1 - The expanding world of protein kinase-like families in bacteria
T2 - forty families and counting
AU - Gradowski, Marcin
AU - Baranowski, Bartosz
AU - Pawłowski, Krzysztof
N1 - Funding Information:
The authors thank Drs Vincent Tagliabracci, Anna Muszewska, and Marcin Grynberg for critical reading of the manuscript. K.P. was supported by the Polish National Agency for Scientific Exchange scholarship PPN/BEK/ 2018/1/00431. K.P. and B.B. were supported by the Polish National Science Centre grant 2017/25/B/NZ1/01883.
Publisher Copyright:
© 2020 The Author(s).
PY - 2020/8
Y1 - 2020/8
N2 - The protein kinase-like clan/superfamily is a large group of regulatory, signaling and biosynthetic enzymes that were historically regarded as typically eukaryotic proteins, although bacterial members have also been known for a long time. In this review, we explore the diversity of bacterial protein kinase like families, and discuss functional versatility of these enzymes, both the ones acting within the bacterial cell, and those acting within eukaryotic cells as effectors during infection. We focus on novel bacterial kinase-like families discovered in the last five years. A bioinformatics perspective is held here, hence sequence and structure comparison overview is presented, and also a comparison of genomic neighbourhoods of the families. We perform a phylum-level census of the families. Also, we discuss apparent pseudokinases that turned out to perform alternative catalytic functions by repurposing their atypical kinase-like active sites. We also highlight some ‘unpopular’ kinase-like families that await characterisation.
AB - The protein kinase-like clan/superfamily is a large group of regulatory, signaling and biosynthetic enzymes that were historically regarded as typically eukaryotic proteins, although bacterial members have also been known for a long time. In this review, we explore the diversity of bacterial protein kinase like families, and discuss functional versatility of these enzymes, both the ones acting within the bacterial cell, and those acting within eukaryotic cells as effectors during infection. We focus on novel bacterial kinase-like families discovered in the last five years. A bioinformatics perspective is held here, hence sequence and structure comparison overview is presented, and also a comparison of genomic neighbourhoods of the families. We perform a phylum-level census of the families. Also, we discuss apparent pseudokinases that turned out to perform alternative catalytic functions by repurposing their atypical kinase-like active sites. We also highlight some ‘unpopular’ kinase-like families that await characterisation.
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U2 - 10.1042/BST20190712
DO - 10.1042/BST20190712
M3 - Review article
C2 - 32677675
AN - SCOPUS:85090052412
SN - 0300-5127
VL - 48
SP - 1337
EP - 1352
JO - Biochemical Society Transactions
JF - Biochemical Society Transactions
IS - 4
ER -