The endocrine heart: B-type natriuretic peptide as a diagnostic and therapeutic agent in cardiovascular disease

Brian D. Le; Tayo A Addo; James A de Lemos

doi:10.1097/01.ten.0000076211.95014.59

The endocrine heart: B-type natriuretic peptide as a diagnostic and therapeutic agent in cardiovascular disease

Brian D. Le, Tayo A Addo, James A de Lemos

Research output: Contribution to journal › Review article › peer-review

1 Scopus citations

Abstract

Since their discovery 20 years ago, natriuretic peptides have rapidly moved to the forefront in cardiovascular medicine, and have contributed to an appreciation that the heart is an important endocrine organ. Of the natriuretic peptides, brain (B-type) natriuretic peptide (BNP) has proven to be the most clinically useful. Physicians now measure circulating levels of BNP and the N-terminal fragment of its prohormone (N-proBNP) for diagnostic and prognostic assessment in patients with suspected congestive heart failure (CHF), and administer recombinant human BNP as a therapeutic agent for patients with decompensated CHF. This review will highlight the mechanisms of natriuretic peptide regulation, the physiologic actions of BNP, and its utilization in patients with cardiovascular diseases.

Original language	English (US)
Pages (from-to)	97-105
Number of pages	9
Journal	Endocrinologist
Volume	13
Issue number	2
DOIs	https://doi.org/10.1097/01.ten.0000076211.95014.59
State	Published - 2003

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism

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abstract = "Since their discovery 20 years ago, natriuretic peptides have rapidly moved to the forefront in cardiovascular medicine, and have contributed to an appreciation that the heart is an important endocrine organ. Of the natriuretic peptides, brain (B-type) natriuretic peptide (BNP) has proven to be the most clinically useful. Physicians now measure circulating levels of BNP and the N-terminal fragment of its prohormone (N-proBNP) for diagnostic and prognostic assessment in patients with suspected congestive heart failure (CHF), and administer recombinant human BNP as a therapeutic agent for patients with decompensated CHF. This review will highlight the mechanisms of natriuretic peptide regulation, the physiologic actions of BNP, and its utilization in patients with cardiovascular diseases.",

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AB - Since their discovery 20 years ago, natriuretic peptides have rapidly moved to the forefront in cardiovascular medicine, and have contributed to an appreciation that the heart is an important endocrine organ. Of the natriuretic peptides, brain (B-type) natriuretic peptide (BNP) has proven to be the most clinically useful. Physicians now measure circulating levels of BNP and the N-terminal fragment of its prohormone (N-proBNP) for diagnostic and prognostic assessment in patients with suspected congestive heart failure (CHF), and administer recombinant human BNP as a therapeutic agent for patients with decompensated CHF. This review will highlight the mechanisms of natriuretic peptide regulation, the physiologic actions of BNP, and its utilization in patients with cardiovascular diseases.

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The endocrine heart: B-type natriuretic peptide as a diagnostic and therapeutic agent in cardiovascular disease

Abstract

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