Abstract
Speckle-type POZ (pox virus and zinc finger protein) protein (SPOP) is an E3 ubiquitin ligase adaptor protein that is frequently mutated in prostate and endometrial cancers. All the cancer-associated SPOP mutations reported to date are clustered in the meprin and TRAF (Tumor necrosis factor receptor-associated factor) homology (MATH) domain, presumably affecting substrate binding. SPOP mutations in prostate cancer are mutually exclusive with the ETS (Erythroblast transformation-specific) family gene rearrangements and define a distinct molecular subclass of prostate cancer. SPOP mutations contribute to prostate cancer development by altering the steady-state levels of key components in the androgen-signaling pathway.
Original language | English (US) |
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Pages (from-to) | 1498-1502 |
Number of pages | 5 |
Journal | Drug Discovery Today |
Volume | 19 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2014 |
ASJC Scopus subject areas
- Pharmacology
- Drug Discovery