The effects of platelet-rich plasma in the treatment of large-joint osteoarthritis: A systematic review

David C. Tietze, Kyle Geissler, James Borchers

Research output: Contribution to journalArticlepeer-review

34 Scopus citations


Context: Osteoarthritis (OA) is a common and costly condition with both operative and nonoperative treatments available. Platelet-rich plasma (PRP) is emerging as a treatment option for a variety of musculoskeletal pathologies, including OA. Objective: To evaluate the effectiveness of intra-articular PRP injection in the treatment of large-joint OA. Data Sources: PubMed, Web of Knowledge, Scopus, and the Cochrane Database were searched. The references of all articles that met the inclusion criteria were manually searched for additional articles. Study Selection: English studies that enrolled human participants were included, with level of evidence I to IV. Results: Thirteen articles met the inclusion criteria: 12 focused on knee OA, and 1 on hip OA. All studies showed statistically significant improvement in patient outcome scores with PRP. Platelet-rich plasma has a statistically significant benefit in knee OA when compared with hyaluronic acid. The benefit from PRP appears to last between 6 and 12 months. Conclusion: Platelet-rich plasma may be an effective treatment for knee OA. However, because of the low level of evidence, small sample sizes, and wide variability in treatment, no definitive recommendations can be made at this time.

Original languageEnglish (US)
Pages (from-to)27-37
Number of pages11
JournalPhysician and Sportsmedicine
Issue number2
StatePublished - 2014


  • Cartilage
  • Chondropathy
  • Hip osteoarthritis
  • Intra-articular injection
  • Knee osteoarthritis
  • Platelet-rich plasma

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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