The effects of nefazodone on sleep architecture in depression

R. Armitage, J. Rush, M. Trivedi, J. Cain, H. P. Roffwarg

Research output: Contribution to journalArticlepeer-review

110 Scopus citations


A polysomnographic study was conducted on 10 outpatients with major depression at baseline and during 4 to 8 weeks of open-trial treatment with nefawdone (400 to 600 mg/day). All 10 patients were treatment responders as evidenced by at least 50% reduction from baseline scores on the Hamilton Depression Rating Scale. Nefazodone was associated with significantly decreased wake and movement time and increased minutes and percentage of stage 2 sleep at the expense of light stage 1 sleep. Nefazodone did not increase rapid-eye-movement (REM) latency and it did not suppress REM sleep. In fact, a trend toward increased REM in the second REM period was observed, although decreased REM in the third REM period was also noted. In summary, nefawdone, an effective antidepressant, decreases arousals and wakefulness during sleep and reduces light non-REM sleep. This agent does not appear to suppress REM sleep or prolong REM latency in patients who respond to treatment.

Original languageEnglish (US)
Pages (from-to)123-127
Number of pages5
Issue number2
StatePublished - Apr 1994


  • 5-HT
  • Antidepressants
  • Depression
  • Electroencephalographic sleep
  • Nefawdone

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health


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