TY - JOUR
T1 - The effects of betamethasone on the amplitude integrated EEG of infants born at 34- or 35-weeks gestation
AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network (NRN)
AU - Eunice Kennedy Shriver National Institute of Child Health and Human Development Maternal-Fetal Medicine Units (MFMU) Network
AU - Laptook, Abbot R.
AU - Chalak, Lina
AU - Pappas, Athina
AU - Davis, Alexis
AU - Sanchez, Pablo J.
AU - Van Meurs, Krisa P.
AU - Oh, William
AU - Sommers, Ross
AU - Shankaran, Seetha
AU - Hensman, Angelita M.
AU - Rouse, Dwight J.
AU - McDonald, Scott
AU - Das, Abhik
AU - Goldberg, Ronald N.
AU - Ambalavanan, Namasivayam
AU - Gyamfi-Bannerman, Cynthia
AU - Thom, Elizabeth A.
AU - Higgins, Rosemary D.
AU - Laptook, Abbot R.
AU - Chalak, Lina
AU - Pappas, Athina
AU - Davis, Alexis
AU - Sanchez, Pablo J.
AU - Van Meurs, Krisa P.
AU - Oh, William
AU - Shankaran, Seetha
AU - Hensman, Angelita M.
AU - McDonald, Scott
AU - Das, Abhik
AU - Goldberg, Ronald N.
AU - Ambalavanan, Namasivayam
AU - Higgins, Rosemary D.
AU - Rouse, Dwight J.
AU - Gyamfi-Bannerman, Cynthia
AU - Thom, Elizabeth A.
N1 - Publisher Copyright:
© 2022, The Author(s), under exclusive licence to Springer Nature America, Inc.
PY - 2022/12
Y1 - 2022/12
N2 - Objective: Assess if maternal betamethasone administration at 34–35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. Study design: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 340–356 weeks gestation before 72 h (aEEG 1) and at 5–7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity. Results: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. Conclusions: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.
AB - Objective: Assess if maternal betamethasone administration at 34–35 weeks accelerated neonatal amplitude integrated EEG (aEEG) maturation. Study design: Nested, observational cohort in 7 centers participating in the Antenatal Late Preterm Steroid randomized trial. Up to 2 aEEGs were obtained in neonates born from 340–356 weeks gestation before 72 h (aEEG 1) and at 5–7 days (aEEG 2) if hospitalized. Personnel and aEEG central readers were masked to the intervention. The primary outcome was maturation reflected by cycle frequency; secondary outcomes were border voltage, span, and discontinuity. Results: 58 neonates were enrolled (betamethasone, 28, placebo, 30). On aEEG 1, cycle frequency did not differ, but betamethasone exposed infants had a greater lower border voltage and a broader span. On aEEG 2, both groups displayed increases in lower border voltage. Conclusions: Betamethasone associated changes in lower border voltage support accelerated electrical activity. Further investigation is needed to understand the broader span.
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U2 - 10.1038/s41372-022-01415-4
DO - 10.1038/s41372-022-01415-4
M3 - Article
C2 - 35618748
AN - SCOPUS:85143180232
SN - 0743-8346
VL - 42
SP - 1615
EP - 1621
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 12
ER -