The Effects of Acid on Calcium and Phosphate Metabolism

Juan D. Salcedo-Betancourt, Orson W. Moe

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations

Abstract

A variety of changes in mineral metabolism aiming to restore acid–base balance occur in acid loading and metabolic acidosis. Phosphate plays a key role in defense against metabolic acidosis, both as an intracellular and extracellular buffer, as well as in the renal excretion of excess acid in the form of urinary titratable acid. The skeleton acts as an extracellular buffer in states of metabolic acidosis, as the bone matrix demineralizes, leading to bone apatite dissolution and the release of phosphate, calcium, carbonate, and citrate into the circulation. The renal handling of calcium, phosphate and citrate is also affected, with resultant hypercalciuria, hyperphosphaturia and hypocitraturia.

Original languageEnglish (US)
Article number2081
JournalInternational journal of molecular sciences
Volume25
Issue number4
DOIs
StatePublished - Feb 2024

Keywords

  • acidosis
  • calcium
  • phosphate

ASJC Scopus subject areas

  • Catalysis
  • Molecular Biology
  • Spectroscopy
  • Computer Science Applications
  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Inorganic Chemistry

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