The effect of tumor location on prognosis in patients with primary ureteral urothelial carcinoma

Wei Ming Li, Wen Jeng Wu, Ching Chia Li, Hung Lung Ke, Yu Ching Wei, Hsin Chih Yeh, Yii Her Chou, Chun Hsiung Huang, Chun Nung Huang

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objectives: To investigate the association of tumor location on oncological outcomes in patients treated with radical nephroureterectomy (RNU) for primary ureteral urothelial carcinoma (UC). Materials and methods: From January 1990 to December 2007, 127 patients with primary solitary ureteral UC who underwent RNU at our institution were included. The patients were divided into 3 groups based on tumor location-proximal, middle, or distal ureter. Patients' medical records were reviewed retrospectively. The clinicopathologic data and oncologic outcomes were compared among the groups. Results: Of the 127 patients, 40 (31.5%) had tumors in the proximal ureter, 40 (31.5%) in the middle ureter, and 47 (37.0%) in the distal ureter. Patients with distal ureteral UC were more likely to undergo open procedures to manage the bladder cuff (P = 0.005). Other clinical and histopathologic variables were not different among the 3 groups. Comparing the proximal, middle, or distal ureteral UC, bladder recurrence developed in, respectively, 25.0%, 25.0%, and 21.3% cases (P = 0.892); local retroperitoneal recurrence in 2.5%, 12.5%, and 4.3% (P = 0.141); contralateral recurrence in 0%, 0%, and 4.3%(P = 0.177); and distant metastasis in 17.5%, 10.0%, and 4.3% (P = 0.147). Recurrence-free and cancer-specific survival among the 3 groups were not different (P = 0.781 and 0.192, respectively). Conclusions: Tumor location cannot be used to predict oncologic outcomes in patients treated with RNU for primary ureteral UC. Therefore, clinical decisions or follow-up protocol should not differ among patients with primary proximal, middle, or distal ureteral UC.

Original languageEnglish (US)
Pages (from-to)1670-1675
Number of pages6
JournalUrologic Oncology: Seminars and Original Investigations
Issue number8
StatePublished - Nov 2013
Externally publishedYes


  • Nephroureterectomy
  • Prognosis
  • Recurrence
  • Ureter
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Oncology
  • Urology


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