The Effect of Proton Pump Inhibitors on Barrett's Esophagus

Kerry B. Dunbar; Rhonda F. Souza; Stuart J. Spechler

doi:10.1016/j.gtc.2015.02.010

The Effect of Proton Pump Inhibitors on Barrett's Esophagus

Kerry B. Dunbar, Rhonda F. Souza, Stuart J. Spechler

Research output: Contribution to journal › Review article › peer-review

22 Scopus citations

Abstract

Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.

Original language	English (US)
Pages (from-to)	415-424
Number of pages	10
Journal	Gastroenterology Clinics of North America
Volume	44
Issue number	2
DOIs	https://doi.org/10.1016/j.gtc.2015.02.010
State	Published - Jun 1 2015

Keywords

Barrett's esophagus
Dysplasia
Esophageal cancer
Gastroesophageal reflux disease
Proton pump inhibitor

ASJC Scopus subject areas

Gastroenterology

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10.1016/j.gtc.2015.02.010

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abstract = "Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.",

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AU - Souza, Rhonda F.

AU - Spechler, Stuart J.

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AB - Proton pump inhibitors (PPIs) may protect against carcinogenesis in Barrett's esophagus because they eliminate the chronic esophageal inflammation of reflux esophagitis, and because they decrease esophageal exposure to acid, which can cause cancer-promoting DNA damage and increase proliferation in Barrett's metaplasia. Most clinical studies of PPIs and cancer development in Barrett's esophagus have found a cancer-protective effect for these drugs, although there are some contradictory data. Chemoprevention of dysplasia and cancer in Barrett's esophagus with PPIs appears to be cost-effective, and the indirect evidence supporting a cancer-protective role for PPIs is strong enough to warrant PPI treatment of virtually all patients with Barrett's esophagus.

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KW - Dysplasia

KW - Esophageal cancer

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The Effect of Proton Pump Inhibitors on Barrett's Esophagus

Abstract

Keywords

ASJC Scopus subject areas

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