The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons

Y. Rubin; M. C. LaPlaca; D. H. Smith; L. E. Thibault; R. E. Lenkinski

doi:10.1016/0304-3940(95)12014-U

The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons

Y. Rubin, M. C. LaPlaca, D. H. Smith, L. E. Thibault, R. E. Lenkinski

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Abstract

We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca²⁺]_i in NTera2-neurons. While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca²⁺]_i, high concentrations of extracellular NAA (3, 10 mM) eliceted sharp and statistically significant elevations of [Ca²⁺]_i. Different classes of antagonists of the N-methyl-d-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca²⁺]_i, indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca²⁺]_i.

Original language	English (US)
Pages (from-to)	209-212
Number of pages	4
Journal	Neuroscience letters
Volume	198
Issue number	3
DOIs	https://doi.org/10.1016/0304-3940(95)12014-U
State	Published - Oct 6 1995

Keywords

Intracellular free calcium
N-acetylaspartate
N-methyl-d-aspartate receptor
NTera2-neurons

ASJC Scopus subject areas

Neuroscience(all)

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10.1016/0304-3940(95)12014-U

Cite this

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title = "The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons",

abstract = "We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca2+]i in NTera2-neurons. While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca2+]i, high concentrations of extracellular NAA (3, 10 mM) eliceted sharp and statistically significant elevations of [Ca2+]i. Different classes of antagonists of the N-methyl-d-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca2+]i, indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca2+]i.",

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AU - LaPlaca, M. C.

AU - Smith, D. H.

AU - Thibault, L. E.

AU - Lenkinski, R. E.

PY - 1995/10/6

Y1 - 1995/10/6

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AB - We have studied the effect of relatively high concentrations of extracellular N-acetylaspartate (NAA) on the intracellular free calcium concentration [Ca2+]i in NTera2-neurons. While low concentrations of extracellular NAA (0.1, 1 mM) had no effect on the [Ca2+]i, high concentrations of extracellular NAA (3, 10 mM) eliceted sharp and statistically significant elevations of [Ca2+]i. Different classes of antagonists of the N-methyl-d-aspartate (NMDA) receptor abolished the NAA induced elevations of the [Ca2+]i, indicating the involvement of the NMDA receptor in NAA-induced elevations of [Ca2+]i.

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KW - N-acetylaspartate

KW - N-methyl-d-aspartate receptor

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The effect of N-acetylaspartate on the intracellular free calcium concentration in NTera2-neurons

Abstract

Keywords

ASJC Scopus subject areas

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