The effect of diphosphonate on calcium phosphate crystallization in urine in vitro

M. Ohata; C. Y C Pak

doi:10.1038/ki.1973.136

The effect of diphosphonate on calcium phosphate crystallization in urine in vitro

M. Ohata, C. Y C Pak

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Abstract

Disodium ethane 1 hydroxy 1,1 diphosphonate (EHDP) was added to human urine in vitro and tested for its effect on nucleation, crystal growth and crystal dissolution of brushite (CaHPO₄ 2H₂O), the probable nidus for certain calcium containing renal stones. The EHDP (0.5 to 8 mg of P/l) increased the formation product of brushite, indicating an inhibition of nucleation of brushite. It inhibited the crystal growth of brushite in every urine specimen tested. Finally, it facilitated the crystal dissolution of brushite in some urine specimens. Thus, EHDP might be clinically useful in the prevention of renal stone formation.

Original language	English (US)
Pages (from-to)	401-406
Number of pages	6
Journal	Kidney international
Volume	4
Issue number	6
DOIs	https://doi.org/10.1038/ki.1973.136
State	Published - 1973

ASJC Scopus subject areas

Nephrology

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10.1038/ki.1973.136

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title = "The effect of diphosphonate on calcium phosphate crystallization in urine in vitro",

abstract = "Disodium ethane 1 hydroxy 1,1 diphosphonate (EHDP) was added to human urine in vitro and tested for its effect on nucleation, crystal growth and crystal dissolution of brushite (CaHPO4 2H2O), the probable nidus for certain calcium containing renal stones. The EHDP (0.5 to 8 mg of P/l) increased the formation product of brushite, indicating an inhibition of nucleation of brushite. It inhibited the crystal growth of brushite in every urine specimen tested. Finally, it facilitated the crystal dissolution of brushite in some urine specimens. Thus, EHDP might be clinically useful in the prevention of renal stone formation.",

author = "M. Ohata and Pak, {C. Y C}",

note = "Funding Information: This study was supported in part by Public Health Funding Information: Service research grant IRO1 AM16O61 and by a grant from the Proctor and Gamble Company. The EHDP used in this study was supplied by the Proctor and Gamble Company. Alan W. Stewart provided technical assistance.",

year = "1973",

doi = "10.1038/ki.1973.136",

language = "English (US)",

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T1 - The effect of diphosphonate on calcium phosphate crystallization in urine in vitro

AU - Ohata, M.

AU - Pak, C. Y C

N1 - Funding Information: This study was supported in part by Public Health Funding Information: Service research grant IRO1 AM16O61 and by a grant from the Proctor and Gamble Company. The EHDP used in this study was supplied by the Proctor and Gamble Company. Alan W. Stewart provided technical assistance.

PY - 1973

Y1 - 1973

N2 - Disodium ethane 1 hydroxy 1,1 diphosphonate (EHDP) was added to human urine in vitro and tested for its effect on nucleation, crystal growth and crystal dissolution of brushite (CaHPO4 2H2O), the probable nidus for certain calcium containing renal stones. The EHDP (0.5 to 8 mg of P/l) increased the formation product of brushite, indicating an inhibition of nucleation of brushite. It inhibited the crystal growth of brushite in every urine specimen tested. Finally, it facilitated the crystal dissolution of brushite in some urine specimens. Thus, EHDP might be clinically useful in the prevention of renal stone formation.

AB - Disodium ethane 1 hydroxy 1,1 diphosphonate (EHDP) was added to human urine in vitro and tested for its effect on nucleation, crystal growth and crystal dissolution of brushite (CaHPO4 2H2O), the probable nidus for certain calcium containing renal stones. The EHDP (0.5 to 8 mg of P/l) increased the formation product of brushite, indicating an inhibition of nucleation of brushite. It inhibited the crystal growth of brushite in every urine specimen tested. Finally, it facilitated the crystal dissolution of brushite in some urine specimens. Thus, EHDP might be clinically useful in the prevention of renal stone formation.

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The effect of diphosphonate on calcium phosphate crystallization in urine in vitro

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