The effect of chronic cardiac denervation on infarct size following acute coronary occlusion

Carl E. Jones, Michael D. Devous, John X. Thomas, Elise DuPont

Research output: Contribution to journalArticlepeer-review

28 Scopus citations


The effect of acute coronary ligation on infarct size was studied in (1) ten acute control dogs, which were non-denervated, (2) in six acutely denervated dogs in which the heart was denervated immediately prior to coronary ligation and in which intra-cardiac reflexes were pharmacologically blocked, (3) in seven chronically denervated dogs in which intrapericardial nerves were cut 2 weeks prior to ligation, and (4) in four dogs which were sham-operated 2 weeks prior to ligation. Infarct size was determined using a nitro blue tetrazolium stain for dehydrogenase activity. Infarct sizes in acute controls, acutely denervated, chronically denervated, and sham-operated hearts were 20.1, 15.0, 3.8, and 21.0 percent of left ventricular weight, respectively. Infarct sizes in acutely and chronically denervated hearts were significantly less than in acute controls (P < 0.05). In further studies the fluorescent stain thioflavin S was used to demonstrate that perfusion of myocardium distal to the ligation was substantially greater in chronically denervated hearts than in acute controls.

Original languageEnglish (US)
Pages (from-to)738-746
Number of pages9
JournalAmerican heart journal
Issue number6
StatePublished - Jun 1978

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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