Abstract
The administration of testosterone cypionate (0.4 mg/kg BW day) to castrated male dogs caused a doubling of prostate weight within 4 weeks and an increase in the content of testosterone and dihydrotestosterone in the prostate. When the 5α-reductase inhibitor 17-N, N-diethylcarbamoyl-4-methyl-4-aza-5α-androstan-3-one (3 mg/kg BW-day) was administeredsimultaneously with testosterone cypionate, prostatic testosterone content increased from 0.5 ± 0.2 to 4.1 ± 1.3 ng/mg DNA, the increase in prostatic dihydrotestosterone content was prevented, and prostatic size decreased to half the starting weight. These results suggest that dihydrotestosterone formation plays a role in prostatic growth.
Original language | English (US) |
---|---|
Pages (from-to) | 569-573 |
Number of pages | 5 |
Journal | Endocrinology |
Volume | 113 |
Issue number | 2 |
DOIs | |
State | Published - Aug 1983 |
ASJC Scopus subject areas
- Endocrinology