TY - JOUR
T1 - The current state of oligometastatic and oligoprogressive non-small cell lung cancer
AU - Tumati, Vasu
AU - Iyengar, Puneeth
N1 - Publisher Copyright:
© Journal of Thoracic Disease.
PY - 2018/8/1
Y1 - 2018/8/1
N2 - Oligometastatic disease is defined as an intermediate state between localized and widespread metastatic disease. Given that in the oligometastatic state gross tumors represent the full extent of disease, there may be a role for curative local therapy despite metastatic disease. As nearly 60% of patients with nonsmall cell lung cancer (NSCLC) present with metastatic disease and another 45% of patients with initially localized disease will ultimately develop distant metastases, NSCLC represents a prime disease for aggressive intervention. In this review, the definition, prognostic factors, patient selection, rationale and evidence for treatment of oligoprogressive and oligometastatic NSCLC is discussed, including recent prospective trials and future directions.
AB - Oligometastatic disease is defined as an intermediate state between localized and widespread metastatic disease. Given that in the oligometastatic state gross tumors represent the full extent of disease, there may be a role for curative local therapy despite metastatic disease. As nearly 60% of patients with nonsmall cell lung cancer (NSCLC) present with metastatic disease and another 45% of patients with initially localized disease will ultimately develop distant metastases, NSCLC represents a prime disease for aggressive intervention. In this review, the definition, prognostic factors, patient selection, rationale and evidence for treatment of oligoprogressive and oligometastatic NSCLC is discussed, including recent prospective trials and future directions.
KW - Metastasectomy
KW - Non-small cell lung cancer (NSCLC)
KW - Oligometastases
KW - Oligoprogressive
KW - Stereotactic ablative radiotherapy (SABR)
KW - Stereotactic body radiation therapy (SBRT)
UR - http://www.scopus.com/inward/record.url?scp=85051259633&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85051259633&partnerID=8YFLogxK
U2 - 10.21037/jtd.2018.07.19
DO - 10.21037/jtd.2018.07.19
M3 - Review article
C2 - 30206497
AN - SCOPUS:85051259633
SN - 2072-1439
VL - 10
SP - S2537-S2544
JO - Journal of Thoracic Disease
JF - Journal of Thoracic Disease
ER -