TY - JOUR
T1 - The consensus coding sequences of human breast and colorectal cancers
AU - Sjöblom, Tobias
AU - Jones, Siân
AU - Wood, Laura D.
AU - Parsons, D. Williams
AU - Lin, Jimmy
AU - Barber, Thomas D.
AU - Mandelker, Diana
AU - Leary, Rebecca J.
AU - Ptak, Janine
AU - Silliman, Natalie
AU - Szabo, Steve
AU - Buckhaults, Phillip
AU - Farrell, Christopher
AU - Meeh, Paul
AU - Markowitz, Sanford D.
AU - Willis, Joseph
AU - Dawson, Dawn
AU - Willson, James K V
AU - Gazdar, Adi F.
AU - Hartigan, James
AU - Wu, Leo
AU - Liu, Changsheng
AU - Parmigiani, Giovanni
AU - Park, Ben Ho
AU - Bachman, Kurtis E.
AU - Papadopoulos, Nickolas
AU - Vogelstein, Bert
AU - Kinzler, Kenneth W.
AU - Velculescu, Victor E.
PY - 2006/10/13
Y1 - 2006/10/13
N2 - The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ∼90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology.
AB - The elucidation of the human genome sequence has made it possible to identify genetic alterations in cancers in unprecedented detail. To begin a systematic analysis of such alterations, we determined the sequence of well-annotated human protein-coding genes in two common tumor types. Analysis of 13,023 genes in 11 breast and 11 colorectal cancers revealed that individual tumors accumulate an average of ∼90 mutant genes but that only a subset of these contribute to the neoplastic process. Using stringent criteria to delineate this subset, we identified 189 genes (average of 11 per tumor) that were mutated at significant frequency. The vast majority of these genes were not known to be genetically altered in tumors and are predicted to affect a wide range of cellular functions, including transcription, adhesion, and invasion. These data define the genetic landscape of two human cancer types, provide new targets for diagnostic and therapeutic intervention, and open fertile avenues for basic research in tumor biology.
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U2 - 10.1126/science.1133427
DO - 10.1126/science.1133427
M3 - Article
C2 - 16959974
AN - SCOPUS:33749993417
SN - 0036-8075
VL - 314
SP - 268
EP - 274
JO - Science
JF - Science
IS - 5797
ER -