The complexity of life and death decisions in mitosis

Laura A. Diaz-Martinez, Hongtao Yu

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


The anticancer drug taxol stabilizes microtubules and activates the spindle checkpoint, causing prolonged mitotic arrest in cancer cells. Our recent work suggests that the cellular decision to live or die following mitotic arrest is a complex process involving crosstalk between competing apoptotic and adaptation pathways.

Original languageEnglish (US)
Article numbere969658
JournalMolecular and Cellular Oncology
Issue number2
StatePublished - Apr 3 2015


  • apoptosis
  • cell death
  • mitochondrial fusion
  • mitosis
  • taxol

ASJC Scopus subject areas

  • Molecular Medicine
  • Cancer Research


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