The complex relationship between center volume and outcome in patients undergoing the norwood operation

Sara K. Pasquali, Jeffrey P. Jacobs, Xia He, Christoph P. Hornik, Robert D.B. Jaquiss, Marshall L. Jacobs, Sean M. O'Brien, Eric D. Peterson, Jennifer S. Li

Research output: Contribution to journalArticlepeer-review

78 Scopus citations


Background: Norwood outcomes vary across centers, and a relationship between center volume and outcome has been previously described. It is unclear whether this volume-outcome relationship exists across all levels of patient risk or holds true for all centers. We evaluated the impact of patient risk status on the relationship between center volume and outcome, and the extent to which differences in center volume account for between-center variation in outcome. Methods: Infants in The Society of Thoracic Surgeons Congenital Heart Surgery Database undergoing the Norwood operation (2000 to 2009) were included. Mortality associated with annual Norwood volume overall and across patient preoperative risk tertiles was evaluated in multivariable analysis. We also estimated the proportion of between-center variation in mortality explained by center volume. Results: The cohort included 2,557 infants from 53 centers: 34 centers with 0 to 10 Norwood cases per year; 13 centers with 11 to 20 cases per year; and 6 centers with more than 20 cases per year. Unadjusted in-hospital mortality was 22%. In multivariable analysis, lower center volume was associated with higher mortality (odds ratio in low-volume versus high-volume centers 1.54, 95% confidence interval: 1.02 to 2.32, p = 0.04). The volume-outcome relationship did not differ across preoperative risk tertiles (p = 0.7). Norwood volume explained an estimated 14% of the between-center variation in mortality observed, and significant between-center variation in mortality remained after adjusting for volume (p < 0.001). Conclusions: Center volume is modestly associated with outcome after the Norwood operation independent of patient risk status. However, this relationship explains only a portion of the between-center variation in mortality in this cohort.

Original languageEnglish (US)
Pages (from-to)1556-1562
Number of pages7
JournalAnnals of Thoracic Surgery
Issue number5
StatePublished - May 2012

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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