The clinical relevance of the clopidogrel-proton pump inhibitor interaction

Atif Mohammad, Emmanouil S. Brilakis, Rick A. Weideman, Bertis B. Little, Subhash Banerjee

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


Proton pump inhibitors are often prescribed concomitantly with clopidogrel and aspirin to patients post-percutaneous coronary interventions and/or an acute coronary syndrome to mitigate the risk of potential gastrointestinal bleeding, associated primarily with clopidogrel use. Over the last several years, there have been data both supporting and refuting a clopidogrel-proton pump inhibitor interaction. This review critically considers the current evidence and provides practical recommendations to healthcare providers.

Original languageEnglish (US)
Pages (from-to)547-552
Number of pages6
JournalJournal of cardiovascular translational research
Issue number4
StatePublished - Aug 2012


  • Clopidogrel
  • Drug interaction
  • Percutaneous coronary intervention
  • Proton pump inhibitor

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmaceutical Science
  • Cardiology and Cardiovascular Medicine
  • Genetics(clinical)


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