The ciliary membrane

Rajat Rohatgi; William J. Snell

doi:10.1016/j.ceb.2010.03.010

The ciliary membrane

Rajat Rohatgi, William J. Snell

Research output: Contribution to journal › Review article › peer-review

137 Scopus citations

Abstract

Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.

Original language	English (US)
Pages (from-to)	541-546
Number of pages	6
Journal	Current Opinion in Cell Biology
Volume	22
Issue number	4
DOIs	https://doi.org/10.1016/j.ceb.2010.03.010
State	Published - Aug 2010

ASJC Scopus subject areas

Cell Biology

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10.1016/j.ceb.2010.03.010

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@article{44b296e757f442ccbec39acf654020d1,

title = "The ciliary membrane",

abstract = "Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.",

author = "Rajat Rohatgi and Snell, {William J.}",

note = "Funding Information: We express our thanks to Olivier Belzile in the Snell Laboratory for providing the original electron micrographs in Figure 1 . Figure 1 A is an adaptation from Gilula and Satir [ 10 • ]. R. Rohatgi is supported in part by NIH ROO CA129174 and WJ Snell is supported in part by NIH GM 25661. ",

year = "2010",

month = aug,

doi = "10.1016/j.ceb.2010.03.010",

language = "English (US)",

volume = "22",

pages = "541--546",

journal = "Current Opinion in Cell Biology",

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T1 - The ciliary membrane

AU - Rohatgi, Rajat

AU - Snell, William J.

N1 - Funding Information: We express our thanks to Olivier Belzile in the Snell Laboratory for providing the original electron micrographs in Figure 1 . Figure 1 A is an adaptation from Gilula and Satir [ 10 • ]. R. Rohatgi is supported in part by NIH ROO CA129174 and WJ Snell is supported in part by NIH GM 25661.

PY - 2010/8

Y1 - 2010/8

N2 - Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.

AB - Cilia and flagella are important organizing centers for signaling in both development and disease. A key to their function is a poorly characterized barrier at their base that allows the protein and lipid composition of the ciliary membrane to be distinct from that of the plasma membrane. We review current models of ciliary membrane biogenesis, highlighting several structures, including the ciliary necklace and ciliary pocket, that appear during biogenesis and that likely contribute to the barrier. The regulated movement of membrane proteins and lipids across this barrier is central to the sensory function of these organelles.

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U2 - 10.1016/j.ceb.2010.03.010

DO - 10.1016/j.ceb.2010.03.010

M3 - Review article

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SN - 0955-0674

VL - 22

SP - 541

EP - 546

JO - Current Opinion in Cell Biology

JF - Current Opinion in Cell Biology

IS - 4

ER -

The ciliary membrane

Abstract

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