The characteristics of relapse in adult-onset minimal-change nephrotic syndrome

Takashi Takei, Minako Koike, Koichi Suzuki, Satsuki Shirota, Mitsuyo Itabashi, Shigeru Ohtsubo, Hidekazu Sugiura, Keiko Suzuki, Chiari Kojima, Masaki Takahashi, Jun Ino, Tetsuya Ogawa, Keiko Uchida, Ken Tsuchiya, Wako Yumura, Kosaku Nitta

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Background. Although minimal-change nephrotic syndrome (MCNS) is highly steroid-responsive, the frequency of relapses in some patients is high, necessitating the administration of repeated courses of prednisolone in high doses. It is, therefore, necessary to identify factors that can predict this increased risk of relapse in some patients in order to establish useful treatment methods to reduce the risk. Methods. To clarify the factors that might increase the risk of relapses, the data of 82 Japanese adult patients with MCNS receiving treatment at our department were analyzed retrospectively. Of the total, 55 patients (67.1%) experienced relapse after showing an initial response. We divided the patients into two groups; namely, the nonrelapse group (n = 27) and the relapse group (n = 55), and compared the clinico- pathophysiological characteristics between the two groups. Results. Significantly increased serum immunoglobulin E (IgE) levels (P = 0.0002) and increased frequency of steroid side effects were observed in the relapse group as compared to the nonrelapse group. Conclusions. To develop effective therapeutic modalities, it is important to have a thorough understanding of the clinico-pathophysiological characteristics of MCNS patients showing relapse.

Original languageEnglish (US)
Pages (from-to)214-217
Number of pages4
JournalClinical and Experimental Nephrology
Issue number3
StatePublished - Sep 2007


  • Immunoglobulin E (IgE)
  • Minimal-change nephrotic syndrome (MCNS)
  • Relapse
  • Steroid side effects

ASJC Scopus subject areas

  • Physiology
  • Nephrology
  • Physiology (medical)


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