The changing face of Sheehan's syndrome

Alex H. Tessnow, Jean D. Wilson

Research output: Contribution to journalReview articlepeer-review

39 Scopus citations


Postpartum necrosis of the anterior pituitary gland is known as Sheehan's syndrome in honor of Harold Leeming Sheehan who characterized the syndrome as the consequence of ischemia after severe puerperal hemorrhage. With advancements of obstetrical care, Sheehan's syndrome has become uncommon except in developing countries. In many affected women, anterior pituitary dysfunction is not diagnosed for many years after the inciting delivery. This review emphasizes the long period of time that may elapse between the puerperal hemorrhage and the eventual diagnosis of hypopituitarism. The pathophysiology, epidemiology, clinical features and treatment of this disorder are discussed.

Original languageEnglish (US)
Pages (from-to)402-406
Number of pages5
JournalAmerican Journal of the Medical Sciences
Issue number5
StatePublished - Nov 2010


  • Adrenal insufficiency
  • Amenorrhea
  • Hypopituitarism
  • Hypothyroidism
  • Postpartum hemorrhage

ASJC Scopus subject areas

  • Medicine(all)


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