Abstract
Hematopoietic stem cells (HSC) are the only cells in the blood-forming tissues that can give rise to all blood cell types and that can self-renew to produce more HSC. In mouse and human, HSC represent up to 0.05% of cells in the bone marrow. HSC are almost entirely responsible for the radioprotective and short- and long-term reconstituting effects observed after bone marrow transplantation. The subsets of HSC that give rise to short-term vs long-term multilineage reconstitution can be separated by phenotype, demonstrating that the fates of HSC are intrinsically determined. Here we review the ontogeny and biology of HSC, their expression of fate-determining genes, and the clinical importance of HSC for transplantation and gene therapy.
Original language | English (US) |
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Pages (from-to) | 35-71 |
Number of pages | 37 |
Journal | Annual Review of Cell and Developmental Biology |
Volume | 11 |
DOIs | |
State | Published - 1995 |
Keywords
- differentiation
- mobilization
- multipotent progenitor
- self-renewal
- transplantation
ASJC Scopus subject areas
- Developmental Biology
- Cell Biology